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Research: PACHECO and COLLEAGUES
Listed in Issue 180
Abstract
PACHECO and COLLEAGUES, Fundacion Ciencia para la Vida, Santiago, Chile. rodrigo.pacheco@bionova.cl review [130 refs] the emerging role of dopamine as a regulator of DC and T-cell physiology and, in turn, immune response.
Background
Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naive T-cells into appropriate effector cells.
Methodology
Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms.
Results
Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DC and T-cell physiology and, in turn, immune response. CONCLUSIONS: Moreover, we discuss how alterations in the dopamine-mediated immune regulatory mechanisms could contribute to the onset of immune-related disorders. [References: 130]
Conclusion
References
Pacheco R, Prado CE, Barrientos MJ and Bernales S, Role of dopamine in the physiology of T-cells and dendritic cells. [Review] [130 refs] Journal of Neuroimmunology, 216(1-2): 8-19. Nov 30 2009.
