Research: PANIC and COLLEAGUES,

Listed in Issue 298

Abstract

PANIC and COLLEAGUES, 1. Section of Hygiene, Institute of Public Health, UniversitĂ  Cattolica del Sacro Cuore, Rome, Italy systematically reviewed the epidemiological evidence for the association between carotenoid intake from natural sources and colorectal cancer s(CRC) development.

Background

Carotenoid intake from natural sources has been hypothesized to reduce the risk of colorectal cancer (CRC). The aim of this study was to systematically review the epidemiological evidence for the association between carotenoid intake from natural sources and CRC development.

Methodology

The authors carried out a systematic review and meta-analysis of epidemiological studies to investigate whether the intake of specific carotenoids from natural sources, as well as combined carotenoids, is associated with the risk of CRC overall and by anatomic subsite. A comprehensive literature search of MEDLINE and Scopus databases was performed. Twenty-two articles were identified from the literature search, of which 16 were case-control studies and 6 were cohort studies.

Results

In the random-effects meta-analysis of case-control and cohort studies, the authors found no association between the intake of individual and total carotenoids and the risk of CRC overall and by anatomic subsite.

Conclusion

Overall, the authors’ findings do not support a significantas combined carotenoids, and the risk of CRC overall and by anatomic subsite.

References

Panic N1, Nedovic D, Pastorino R, Boccia S, Leoncini E. Carotenoid intake from natural sources and colorectal cancer: a systematic review and meta-analysis of epidemiological studies. Eur J Cancer Prev ;26(1):27-37. Jan 2017.

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