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Research: PARIZADEH and COLLEAGUES,
Listed in Issue 177
Abstract
PARIZADEH and COLLEAGUES, Department of Nutrition and Biochemistry, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran studied the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) in Iranian patients.
Background
This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients.
Methodology
Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols.
Results
Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD.
Conclusion
References
Parizadeh SM, Moohebati M, Ghafoori F, Ghayour-Mobarhan M, Kazemi-Bajestani SM, Tavallaie S, Azimi-Nezhad M and Ferns GA. Serum selenium and glutathione peroxidase concentrations in Iranian patients with angiography-defined coronary artery disease. Angiology. 60(2):186-91. Apr-May 2009.
