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Research: PETERS and colleagues,
Listed in Issue 144
Abstract
PETERS and colleagues, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA, upeters@fhcrc.org, have studied selenium and the risk of prostate cancer.
Background
Selenium is a potential chemopreventive agent against prostate cancer. Its effects are possibly mediated through the antioxidative properties of selenium-dependent enzymes. Interrelations with other antioxidative agents and oxidative stressors, such as smoking, are poorly understood. The aims of this study were to investigate the association between serum selenium and prostate cancer risk, and to examine interactions with other antioxidants and tobacco use.
Methodology
A nested case-control study was performed with data from a larger trial. Serum selenium in prospectively collected samples was compared between 724 incident prostate cancer case subjects and 879 control subjects, frequency-matched for age, time since initial screen, and year of blood draw. The men were followed for up to 8 years.
Results
Overall, serum selenium was not associated with prostate cancer risk (p for trend = 0.70). However, higher serum selenium was associated with lower risks in men reporting a high (more than the median) vitamin E intake (odds ratio for the highest compared with the lowest quartile of selenium: 0.58; p for trend = 0.05) and in multivitamin users (odds ratio for highest compared with the lowest quartile of selenium: 0.61; p for trend = 0.06). Furthermore, among smokers, high serum selenium concentrations were related to reduced prostate cancer risk (odds ratio for the highest compared with the lowest quartile of selenium: 0.65; p for trend = 0.09).
Conclusion
Overall, serum selenium concentrations were not associated with prostate cancer risk in this large cohort, although selenium concentration was associated with reduced prostate cancer risks in men who reported a high intake of vitamin E, in multivitamin users, and in smokers.
References
Peters U, Foster CB, Chatterjee N, Schatzkin A, Reding D, Andriole GL, Crawford ED, Sturup S, Chanock SJ Hayes RB. Serum selenium and risk of prostate cancer-a nested case-control study. American Journal of Clinical Nutrition 85 (1): 209-217, Jan 2007.
