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Research: ROSMAN-URBACH and co-workers,
Listed in Issue 140
Abstract
ROSMAN-URBACH and co-workers, Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel, have investigated the nutritional habits of patients at risk from colorectal cancer.
Background
Ulcerative colitis patients have an increased risk of developing colorectal cancer compared with the normal population. The cause underlying this higher risk is not fully defined but includes nutritional and environmental factors concomitant with genetic alterations. The aim of this study was to evaluate genetic stability in the colon tissue of ulcerative colitis patients in clinical remission compared with the healthy population, and to establish a possible correlation between nutritional habits and these molecular assessments.
Methodology
42 ulcerative colitis patients and 37 healthy controls participated in the study. All participants were histopathologically and medically diagnosed. Participants completed 5 separate 7 day dietary records, food-frequency questionnaires and validated 24 hour recalls for nutritional assessment. The extent of chromosome 17 loss and the calculated chromosome index was determined in colon tissue. Correlations between the molecular and nutritional assessments were performed using Pearson’s correlation coefficients.
Results
Significant differences in the nutritional intake of total fat (65 v. 89 g), cholesterol (330 v. 464 mg), dietary fibre (32 v. 9 g), vitamin A (1009 v. 506 microg), vitamin C (308 v. 72 mg) and folic acid (412 v. 187 microg) were recorded for ulcerative colitis patients compared with controls. Significant correlations were found for the consumption of different food groups and the chromosome index for chromosome 17.
Conclusion
The results of this study suggest that the nutritional habits adopted by ulcerative colitis patients during clinical remission may affect key cellular components of the colon tissue, inducing a high degree of genetic instability, and probably affecting the development of colon cancer.
References
Rosman-Urbach M et al. Relationship between nutritional habits adopted by ulcerative colitis relevant to cancer development patients at clinical remission stages and molecular-genetic parameters. British Journal of Nutrition 95 (1): 188-195, Jan 2006.
