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Research: Sargeant and colleagues,
Listed in Issue 62
Abstract
Sargeant and colleagues, Department of Community Medicine, University of Cambridge, Institute of Public Health, UK. lincoln.sargeant@srl.cam.ac.uk examined Vitamin C and hyperglycaemia in the European Prospective Investigation into Cancer—Norfolk (EPIC-Norfolk) study.
Background
Methodology
Data from a population-based study of diet, cancer, and chronic disease were analysed. A total of 2,898 men and 3,560 women 45-74 years of age who were registered with general practices in Norfolk, UK, were recruited to the European Prospective Investigation Into Cancer-Norfolk study between 1995 and 1998.
Results
Mean plasma vitamin C levels were significantly higher in individuals with HbA1c levels < 7% than in those with self-reported diabetes or prevalent undiagnosed hyperglycaemia (HbA1c > or = 7%). An inverse gradient of mean plasma vitamin C was found in both sexes across quintiles of HbA1c distribution < 7%. The odds ratio of having prevalent undiagnosed hyperglycaemia per 20 micromol/l (or 1 SD) increase in plasma vitamin C was 0.70 (adjusted for sex, age, BMI, waist-to-hip ratio, tertiary education, any use of dietary supplements, vegetarian diet, alcohol consumption, physical activity, dietary vitamin E, dietary fibre, dietary saturated fat, and smoking history).
Conclusion
An inverse association was found between plasma vitamin C and HbA1c. Dietary measures to increase plasma vitamin C may be an important public health strategy for reducing the prevalence of diabetes .
References
Sargeant LA et al. Vitamin C and hyperglycaemia in the European Prospective Investigation into Cancer—Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care 23(6): 726-32. Jun 2000.
