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Research: SEELY and colleagues,
Listed in Issue 149
Abstract
SEELY and colleagues, New Agents and Innovative Therapy Program, Division of Hematology/Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, have reviewed (155 references) strategies for controlling potential interactions between natural health products and chemotherapy.
Abstract: The high prevalence of complementary and alternative medicine use including natural health products in the paediatric oncology population is well established. The potential for concurrent use of natural health products with conventional chemotherapy necessitates physician awareness regarding the potential risks and benefits that might come from this co-administration. Knowledge of interactions between natural health products and chemotherapy is poorly characterized; however, an understanding of potential mechanisms of interaction by researchers and clinicians is important. Concerns regarding the use of antioxidants during chemotherapy are controversial and evidence exists to support both adherents and detractors in this debate. This review addresses issues regarding potential interactions between natural health products and chemotherapies used in paediatric oncology from a pharmacokinetic and pharmacodynamic perspective. Examples of combinations of natural health products and chemotherapies are briefly presented in addition to a strategy to avoid (or induce) a possible interaction between a natural health product and chemotherapy. In conclusion, more clinical research is needed to substantiate or preclude the use of natural health products in the treatment of cancer and especially in combination with chemotherapy.
Background
Methodology
Results
Conclusion
References
Seely D, Stempak D, Baruchel S. A strategy for controlling potential interactions between natural health products and chemotherapy: a review in pediatric oncology. Journal of Pediatric Hematology/Oncology 29 (1): 32-47, Jan 2007.
