Positive Health Online

Abstract

SIEJA and TALERCZYK, Department of Pharmacology, Pomeranian Academy of Medicine, Szczecin, Poland, ldoroz@uoo.univ.szczecin.pl, have investigated the influence of selenium on women undergoing treatment for ovarian cancer.

Background

The aim of the study was to examine the effect of selenium supplementation on oxidative stress (as measured by malondialdehyde concentrations) in women undergoing chemotherapy for ovarian cancer.

Methodology

31 women undergoing chemotherapy for ovarian cancer were given 200 micrograms of selenium daily.

Results

The women who were supplemented with selenium showed significantly higher concentrations of selenium in blood and hair compared to controls. They showed a significant increase in the activity of the enzyme, glutathion peroxidase after 2 months' supplementation, a significant increase on malondialdehyde and an increase in white blood cell counts. Hair loss decreased significantly with the supplementation, as well as flatulence, abdominal pain, weakness, malaise, and loss of appetite.

Conclusion

The authors conclude that selenium supplementation ha a significant role in the support of patients undergoing chemotherapy for ovarian cancer.

References

Sieja K, Talerczuk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecologic oncology 93 (2): 320-327, May 2004.

Comment

The above studies further demonstrate the role of selenium both in ovarian cancer and as an adjunct treatment to chemotherapy for ovarian cancer.