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Research: STOLZENBERG-SOLOMON and c
Listed in Issue 69
Abstract
STOLZENBERG-SOLOMON and colleagues, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA, rs221z@nih.gov, investigated the association of Helicobacter pylori carriage and exocrine pancreatic cancer in male Finnish smokers.
Background
Gastric carriage of H. pylori (particularly cytotoxin-associated gene-A-positive (CagA+) strains) is known to be a risk factor for peptic ulcer disease and gastric cancer and may also be a risk factor for pancreatic cancer.
Methodology
In a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (total n=29,133), 121 male Finnish smokers (aged 50-69 years at baseline) were matched on date of baseline serum collection, study centre, age, trial intervention and completion of dietary questionnaire to 226 control subjects who were alive at the time the matching case subject was diagnosed and who remained free of cancer during up to 10 years of follow-up. Levels of immunoglobulin G (IgG) antibodies to H. pylori whole-cell and CagA+ antigens from stored baseline serum were measured by enzyme-linked immunosorbent assay (ELISA). Smoking-adjusted ORs and 95% CIs were estimated using conditional logistic regression. Statistical tests were two-sided.
Results
Seroprevalence of H. pylori was 82% and 73% among case and control subjects respectively. Compared with seronegative subjects, those with H. pylori or CagA+ strains were at statistically significantly elevated risk of pancreatic cancer (OR 1.87, 95% CI 1.05, 3.34 and OR 2.01, 95% CI 1.09, 3.70 respectively)
Conclusion
The findings support a possible role of H. pylori carriage in the development of exocrine pancreatic cancer .
References
Stolzenberg-Solomon RZ et al. Helicobacter pylori seropositivity as a risk factor for pancreatic cancer. Journal of the National Cancer Institute 93 (12): 937-41. Jun 2001.
