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Research: SUNKIREDDY and COLLEAGUES,
Listed in Issue 244
Abstract
SUNKIREDDY and COLLEAGUES, (1)TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi 110003, India review the literature regarding natural antioxidants in future nanomedicine based therapy for cataract.
Background
Cataract is an eye disease of major human concern and its prevention is important to control the global incidences of blindness.
Methodology
The emergence of cataract in the eye lens by strong UV radiation and growing pollution could be effectively reduced by natural antioxidant biomolecules such as flavonoids, phenolic acids, carotenoids and vitamins.
Results
This goal can be achieved either by direct external use of antioxidant biomolecules in the form of topical application as an eye drops, food supplements or through nanobiotechnology based formulation without any side effects. In this manuscript, we have discussed the mechanisms of cataract formation and the preventive role of different classes of natural antioxidant biomolecules.
Conclusion
Further, role of nanobiotechnology to enhance therapeutic potential of these natural antioxidant molecules by enhancing solubility, stability, bioavailability and sustained release has been briefly discussed.
References
Sunkireddy P(1), Jha SN, Kanwar JR, Yadav SC. Natural antioxidant biomolecules promises future nanomedicine based therapy for cataract. Colloids Surf B Biointerfaces. 112:554-62. Dec 1 2013. doi: 10.1016/j.colsurfb.2013.07.068. Epub Aug 14 2013.
