Positive Health Online

Abstract

TASCA and COLLEAGUES, 1 Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil; 2 Department of Pathology, FMB, UNESP, Botucatu, SP, Brazil; 3 Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy analyzed markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients and the presence or absence of antiretroviral treatment (cART).

Background

We aimed to analyze markers of immune activation, inflammation, and oxidative stress in 92 asymptomatic HIV-infected patients according to the adequate (AR, >500 cells/mm3) or inadequate (IR, <500 cells/mm3) CD4+ T recovery and the presence or absence of antiretroviral treatment (cART).

Methodology

In relation to those newly diagnosed, they were divided into two groups, cART-naïve IR (nIR) and cART-naïve AR (nAR). Among those diagnosed more than five years ago, the following division was made: the cART-naïve long-term nonprogressors (LTNP); patient under cART and AR (tAR); and patients under cART and IR (tIR). We investigated the expression of soluble receptor for advanced glycation end products (sRAGE), high-mobility group-box protein -1 (HMGB1), soluble CD14 (sCD14), IL-8, IL-10, 8-isoprostane, vitamins, and DNA damage.

Results

We observed higher levels of sRAGE in tAR as compared to nIR, nAR, LTNP, and more sCD14 than in nIR and nAR. As for IL-10 levels, we found nIR > nAR > LTNP > tAR > tIR. Higher levels of 8-isoprostane were observed in nIR. LTNP presented a higher retinol dosage than tAR and less genotoxic damage induced by oxidative stress than the other groups.

Conclusion

We suggest that the therapy, despite being related to lesser immune activation and inflammation, alters the vitamin profile and consequently increases the oxidative stress of patients. In addition, the lowest genotoxic index for LTNP indicates that both VL and cART could be responsible for the increased DNA damage. More studies are needed to understand the influence of cART on persistent immune activation and inflammation.

References

Karen Ingrid Tasca  1 , Camila Renata Correa  2 , Juliana Trindade Caleffi  1 , Monica Banwart Mendes  1 , Mariana Gatto  1 , Vanessa Martinez Manfio  1 , Caio Cavassan de Camargo  1 , Francilene Capel Tavares  1 , Mara Biasin  3 , Lenice do Rosário de Souza  1. Asymptomatic HIV People Present Different Profiles of sCD14, sRAGE, DNA Damage, and Vitamins, according to the Use of cART and CD4 + T Cell Restoration J Immunol Res.  ;2018:7531718. doi: 10.1155/2018/7531718. eCollection 2018. Apr 10 2018.