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Research: TAYLOR and others,
Listed in Issue 96
Abstract
TAYLOR and others, Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-8314, USA, ptaylor@mail.nih.gov, have investigated the link between serum vitamin E levels and cancer of the oesophagus and stomach.
Background
It was found that participants in the General Population Trial, a randomized nutritional supplementation trial in Linxian, China, in which participants were given selenium, vitamin E, and beta-carotene, had lower cancer mortality rates than people who did not receive the supplement. In this case cohort study, the data were used to examine the connection between vitamin levels pre trial and cancers of the oesophagus and stomach was examined.
Methodology
Serum alpha- and gamma-tocopherol levels were determined in 1072 cancer patients (either oesophageal squamous cell carcinoma, gastric cardia cancer, or gastric non-cardia cancer) and in 1053 control subjects.
Results
The relative risk of cancer for the highest compared to the lowest quartile of alpha-tocopherol was 0.63 for the oesophageal cancer and 0.84 for the gastric cardia cancer. No correlation between the serum levels of gamma-tocopherol and cancer risk was detected.
Conclusion
These data support a role of alpha-tocopherol (vitamin E) in the prevention of upper gastrointestinal cancers. Tsylor PR, Qiao YL, Abnet CC, Dawsey SM, Yang CS, Gunter EW, Wang W, Blot WJ,
References
Dong ZW, Mark SD. Prospective study of serum vitamin E levels and esophageal and gastric cancers. Journal of the National Cancer Institute 95 (18): 1414-1416, Sep 2003.
