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Research: TEWTRAKUL and co-workers,
Listed in Issue 93
Abstract
TEWTRAKUL and co-workers, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan, have described HIV-1 integrase inhibitory substances from the plant Coleus parvifolius.
Background
The enzyme HIV-1 integrase is essential for the replication of human immunedeficiency virus (HIV-1). Thus any natural compound that inhibits the activity of this enzyme can be expected to have the effect of inhibiting the spread of HIV.
Methodology
Extracts from 50 Thai plants were screened for their inhibitory activity against HIV-1 integrase in vitro.
Results
An alcoholic extract of Coleus parvifolius Benth. showed potent activity against the HIV enzyme. From this extract, 11 different chemical compounds were isolated and identified. Of these, 4 showed inhibitory activity against the enzyme in the micromolar range.
Conclusion
The Thai plant, Coleus parvifolius, has the potential for anti-HIV activity. Tewtrakul S, Miyashiro H, Nakamura N, Hattori M, Kawahata T, Otake T, Yoshinaga T, Fujiwara T, Supavita T,
References
Yuenyongsawad S, Rattanasuwon P, Dej AS. HIV-1 integrase inhibitory substances from Coleus parvifolius. Phytotherapy Research 17 (3): 232-239, Mar 2003.
