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Research: TOKUDOME and co-workers,
Listed in Issue 89
Abstract
TOKUDOME and co-workers, Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Japan, tokudome@med.nagoya-cu.ac.jp, present the rationale and study design of dietary intervention in patients operated for tumours of the colorectum. The authors have implemented a randomized controlled dietary intervention in patients who have undergone polypectomy for tumours of the colorectum, in order to elucidate potential benefits of n-3 polyunsaturated fatty acids on the development of colorectal tumours. Individuals in the experimental group were advised not only to decrease their total intake of fatty and oily foods, specifically those containing n-6 polyunsaturated fatty acids, but also to increase specifically foods containing n-3 polyunsaturated fatty acids. Those in the control group were cautioned to reduce their total fat intake. Patient compliance and adherence to advice was assessed with a semi-quantitative food frequency questionnaire, and also by measuring fatty acid concentrations in plasma, red blood cell membranes, and sigmoid colon samples. For endpoints to assess tumour suppressive effects of n-3 polyunsaturated fatty acids, the number/multiplicity, sizes and incidence of colorectal tumours were compared between experimental and control group after 12 and 24 months. On the specified assumption, the number of pairs needed for statistical significance was calculated to be approximately 60-80. A randomized controlled trial is under way to secure sufficient patient numbers, sustain compliance and minimize dropouts.
Background
Methodology
Results
Conclusion
References
Tokudome S, Yokoyama K, Kamiya T, Seno K, Okuyama H, Kuriki K, Cheng J, Nakamura T, Fujii T, Ichikawa H, Itoh M. Rationale and study design of dietary intervention in patients polypectomized for tumours of the colorectum. Japanese Journal of Clinical Oncology 32 (12): 550-553, Dec 2002.
Comment
The above research studies demonstrate the considerable evidence accumulating regarding the therapeutic benefits of vitamins A, C and E and various essential fatty acids in the prevention and treatment of a number of cancers.
