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Research: VATASSERY and colleagues
Listed in Issue 36
Abstract
VATASSERY and colleagues, GRECC, VA Medical Center, Department of Psychiatry, University of Minnesota, Minneapolis 55417 USA studied the association of alpha-tocopherol (vitamin E) concentrations and Parkinson's disease.
Background
Methodology
The concentration of alpha-tocopherol was determined in the cerebral spinal fluid (CSF) in patients with early untreated Parkinson's disease. Patients received 2,000 IU vitamin E orally each day.
Results
Following treatment, concentrations increased significantly by 76+%. Net increases in CSF alpha-tocopherol concentrations following treatment showed a significant positive correlation with the number of days of vitamin E intake.
Conclusion
High-dose vitamin E treatment results in an elevation of vitamin E CSF levels and possibly brain vitamin E levels.
References
Vatassery GT et al. Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group. Neurology 50(6): 1900-2. June 1998.
