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Research: VINCENT and colleagues,
Listed in Issue 107
Abstract
VINCENT and colleagues, Unit 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), Faculty of Medicine Timone, Mediterranee University, 27 boulevard Jean Moulin, F-13385 Marseille Cedex 5, France, introduce the Medi-RIVAGE study, a study on Mediterranean diet, cardiovascular disease risk and genetic polymorphism.
Background
The aim of this paper is to report the rationale, recruitment, design, dietary intervention and baseline characteristics of participants in the Medi-RIVAGE study.
Methodology
In this randomized, parallel trial comparing a new nutritional programme with a conventional programme, 212 volunteers with at least one cardiovascular risk factor participated. A Mediterranean-type diet characterized mainly by the quality of fatty acids, amount of fish, vegetables and fibre was proposed and compared with a usually prescribed, low-fat/cholesterol diet. Body mass index, fasting lipids and lipoproteins, apolipoproteins, glucose, insulin and homocysteine were the main outcome measures. Gene polymorphisms of interest were determined.
Results
The men in the two arms of the study had very similar demographic and health variables. Among women, there were a few differences in cholesterol levels at baseline. There was no difference between arms in allelic distribution of the gene polymorphisms studied. At baseline, all subjects had a high intake of protein and saturated fat and a low intake of carbohydrate and fibre. Correlations between nutritional intakes and plasma nutrient levels ranged from 0.19 (beta-carotene) to 0.47 (folate).
Conclusion
The comparability of the two study arms is notable and warrants a low risk of biases. The habitual diet of participants differs markedly from the traditional Mediterranean one. The assessment of nutritional intake is validated by correlations obtained between dietary intake and relevant biomarkers. This will be important to estimate participant compliance and to analyze intervention data.
References
Vincent S, Gerber M, Bernard MC, Defoort C, Loundou A, Portugal H, Planells R, Juhan-Vague I, Charpiot P, Grolier P, Amiot-Carlin MJ, Vague P, Lairon D. The Medi-RIVAGE study (Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms): rationale, recruitment, design, dietary intervention and baseline characteristics of participants. Public Health Nutrition. 7(4): 531-42, Jun 2004.
