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Research: VOGT and co-workers,
Listed in Issue 90
Abstract
VOGT and co-workers, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7246, USA, review (53 references) serum selenium and the risk of prostate cancer in black and white Americans.
Background
Prostate cancer is the most common cancer in men in the USA, with incidence rates in black men being the highest in the world. The aetiology of the disease and the reasons for this disparity in black and white men remain unknown. Here, the hypothesis is tested that there might be a connection with selenium which is known to act as preventive against prostate cancer.
Methodology
Selenium concentrations were measured in the blood serum of 212 patients with prostate cancer and 233 healthy controls that included comparable numbers of black and white American men aged between 40 and 79.
Results
Serum selenium was inversely associated with the risk of prostate cancer, with similar patterns in black and white men. It was also found that this inverse association with selenium was strongest in men with low serum vitamin E concentrations.
Conclusion
A moderately decreased risk of prostate cancer at higher selenium concentrations is shown. This finding can now be extended to black men across the USA.
References
Vogt TM, Ziegler RG, Graubard BI, Swanson CA, Greenberg RS, Schoenberg JB, Swanson GM, Hayes RB, Mayne ST. Serum selenium and risk of prostate cancer in US blacks and whites. International Journal of Cancer 103 (5): 664-670, Feb 2003.
