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Research: VON GRUENIGEN and co-workers,
Listed in Issue 96
Abstract
VON GRUENIGEN and co-workers, Department of Obstetrics and Gynecology, SUMMA Health System, 525 E. Market Street, Akron, OH 44309, USA, vivian.vongruenigen@uhhs.com, have tested the in vitro activity of vitamins C and K3 against ovarian cancer.
Background
The aim of the study was to evaluate the cytotoxic effect and mechanism of action of vitamins C and K3 on ovarian carcinoma cell lines.
Methodology
Cytotoxicity assays were performed on ovarian cancer cell lines with vitamin C, vitamin K3, or a combination of both. In addition, light and electron microscopy and DNA isolation were carried out.
Results
Antitumour activity was found by all three treatments. Vitamins C and K3 demonstrated synergistic activity. The combination of the two vitamins may induce a block in the cell cycle at the G1 stage. Degradation of chromosomal DNA was observed. Dying cells displayed characteristics of both apoptosis and necrosis.
Conclusion
Vitamins C and K3 show cytotoxic activity against ovarian cancer cells. The effects observed may enable vitamins C and K3 to play an adjuvant role in the treatment of ovarian cancer.
References
Von Gruenigen VE, Jamison JM, Gilloteaux J, Lorimer HE, Sumers M, Pollard RR, Gwin CA, Sumers JL. The in vitro antitumor activity of vitamins C and K3 against ovarian carcinoma. Anticancer Research 23 (4): 3279-3287, Jul 2003.
Comment
The above research provides considerable documentation regarding the cytotoxic effects of a number of nutrients against a variety of cancers, including gallbladder, oesophageal, gastric cardia and ovarian. If antioxidants were valuable, like pharmaceutical drugs, these results would be appearing on the News Bulletins, with projections of cures during the next 5 years. Instead, there is this outpouring of research results, and total silence about these developments from the media and the medical world. Such a grave pity!
