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Research: WANG and co-workers, A
Listed in Issue 86
Abstract
WANG and co-workers, Affiliated Hospital of Nantong Medical College, Nantong 226001, China, found an alteration of vitamin E levels in patients with pancreatic adenocarcinoma .
Background
The objective of this study was to investigate the alterations in vitamin E levels in patients with pancreatic adenocarcinoma and explore its mechanism of action.
Methodology
A comparative analysis of serum vitamin E levels was conducted in patients with various pancreatic diseases .
Results
Patients with chronic pancreatitis, acute pancreatitis, and pancreatic adenocarcinoma all had significantly lower serum vitamin E levels than healthy controls . Amongst the three groups of pancreatic diseases, patients with carcinoma had significantly lower vitamin E levels than either of the other two disorders .
Conclusion
Significant reduction in vitamin E levels occurs in patients with pancreatic cancer . This suggests that oxidation and anti-oxidation imbalances might be involved in the pathogenesis of pancreatic adenocarcinoma.
References
Wang DF, Qu XC, Dai ZQ, et al. Alteration of vitamin E levels in patients with pancreatic adenocarcinoma. Ti I Chuen I Ta Hsueeh Hsueeh Pao 22 (3): 210-211, Mar 2002.
