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Research: WEBER, F Hoffmann-La R
Listed in Issue 50
Abstract
WEBER, F Hoffmann-La Roche Ltd, Vitamins and Fine Chemicals Division, Human Nutrition and Health, Basel, Switzerland reviews (41 references) the main role vitamins are believed to play in the prevention of osteoporosis .
Background
Methodology
Results
and Discussion : Vitamin D improves bone strength mainly by increasing intestinal calcium absorption and reabsorption of calcium by the kidney. Research in humans has demonstrated that vitamin D can improve bone status as measured by bone density. Vitamin C is considered to an essential cofactor of collagen formation and epidemiological studies demonstrate a positive association between vitamin C intake and bone density; however intervention studies regarding the effect of vitamin C upon bone status have not been conducted. Vitamin B6 may function as a cofactor to build up cross-links; however, there is little evidence in humans to support this. Vitamin K is required for the activity of several coagulation factors. Recent research also suggests a role for vitamin K in bone metabolism, in that vitamin K mediates the carboxylation of glutamyl residues on several bone proteins, including osteocalcin. Results from epidemiological studies and intervention trials consistently suggest that vitamin K may improve bone health.
Conclusion
References
Weber P. The role of vitamins in the prevention of osteoporosis a brief status report. International Journal for Vitamin and Nutrition Research 69(3): 1947. May 1999.
