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Research: WILASRUSMEE and colleague
Listed in Issue 86
Abstract
WILASRUSMEE and colleagues, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA, conducted an in vitro investigation of immunomodulatory effects of herbal products .
Background
The effect of herbal products on immune response has not been investigated . Because these products can affect the host immune system, they may induce either rejection of tolerance after a transplant procedure.
Methodology
In vitro lymphocyte proliferation tests were performed using phytohaemagglutinin, mixed lymphocyte culture assay, and interleukin-2 and interleukin-10 production. 10 commonly used herbal products were assessed for their effects.
Results
Dong quai, ginseng, and milk thistle had nonspecific immunostimulatory effects. Ginger and green tea had immunosuppressive effects. The immunosuppressive effect of ginger and green tea was mediated through a decrease in interleukin-2 production.
Conclusion
Green tea, dong quai, ginseng, milk thistle, and ginger have effects on in vitro immunoassays that may be relevant to patients who have had transplants .
References
Wilasrusmee C, Siddiqui J, Bruch D, Wilasrusmee S, Kittur S, Kittur DS et al. In vitro immunomodulatory effects of herbal products. The American Surgeon 68 (10): 860-864, Oct 2002.
