Positive Health Online

Abstract

WOELK, Klinik fur Psychiatrie und Psychotherapie, Akademisches Lehrkrankenhaus der Universitat Giessen, Licher Strasse 106, D-35394 Giessen, Germany compared St John's Wort and imipramine in treating mild to moderate depression .

Background

Methodology

Randomized, multicentre, double blind, parallel group trial. There were 324 participants from 40 outpatient clinics in Germany. Participants were given 75 mg imipramine twice daily or 250 mg hypericum extract ZE 117 twice daily for 6 weeks. Results were assessed using the Hamilton depression rating scale, clinical global impression scale, and patient's global impression scale.

Results

Among the 157 participants taking hypericum mean scores on the Hamilton depression scale decreased from 22.4 at baseline to 12.00 at end point; among the 167 participants taking imipramine they fell from 22.1 to 12.75. Mean clinical global impression scores at end point were 2.22 out of 7 for the hypericum group and 2.42 for the imipramine group. On the 7 point self assessments of global improvement completed by participants (score of 1 indicating 'very much improved' and 7 indicating 'very much deteriorated') mean scores were 2.44 in the hypericum group and 2.60 in the imipramine group. None of the differences between treatment groups were significant. However, the mean score on the anxiety-somatisation subscale of the Hamilton scale (3.79 in the hypericum group and 4.26 in the imipramine group) indicated a significant advantage for hypericum relative to imipramine. Mean scores on the 5 point scale used by participants to assess tolerability (score of 1 indicating excellent tolerability and 5 indicating very poor tolerability) were better for hypericum (1.67) than imipramine (2.35). Adverse events occurred in 62/157 (39%) participants taking hypericum and in 105/167 (63%) taking imipramine. 4 (3%) participants taking hypericum withdrew because of adverse events compared with 26 (16%) taking imipramine.

Conclusion

This Hypericum perforatum extract is therapeutically equivalent to imipramine in treating mild to moderate depression, but patients tolerate hypericum better .

References

Woelk H. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial British Medical Journal 321(7260): 536-9. Sep 2000.