Positive Health Online

Abstract

WU and colleagues, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, Heilongjiang Province, China, wukun@ems.edu.cn, have described the effects of vitamin E on human stomach cancer cells.

Background

The study aimed to investigate the effect of vitamin E succinate on human gastric carcinoma and the mechanism of this effect.

Methodology

Human gastric carcinoma cells in culture, and human gastric carcinoma tissues, were treated with varying amounts of vitamin E succinate. The expression of the proteins Fas and PCNA was measured.

Results

The expression of the protein Fas rose with increased amounts of vitamin E present in a dose-dependent fashion. The expression of the protein PCNA decreased with increasing vitamin E concentration.

Conclusion

Vitamin E succinate inhibited the growth of gastric cancer cells by inducing Fas expression and suppressing PCNA expression. It is therefore likely that Fas and PCNA may be useful clinical parameters to predict the success of vitamin E therapy in stomach cancer.

References

Wu K, Zhao L, Li Y, Shan YJ, Wu LJ. Effects of vitamin E succinate on the expression of Fas and PCNA proteins in human gastric carcinoma cells and its clinical significance. World Journal of Gastroenterology 10 (7): 945-949, Apr 2004.