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Research: YEH and COLLEAGUES,
Listed in Issue 169
Abstract
YEH and COLLEAGUES, Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA studied the association between dietary intake of vegetables and related nutrients and risk of endometrial cancer (EC).
Background
A limited number of studies have investigated diet in association with endometrial cancer (EC).
Methodology
We examined the association between intakes of selected food groups and nutrients with EC risk among 541 women with histologically confirmed EC and 541 women with an intact uterus and noncancer diagnoses seen at Roswell Park Cancer Institute between 1982 and 1998. Self-reported dietary and other epidemiologic data were collected by questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% CI, adjusting for age, BMI, hormone replacement therapy use, cigarette smoking, lifetime duration of menstruation, and total energy intake.
Results
The authors observed significant inverse associations for women in the highest vs. lowest quartiles of intake of total vegetables (OR, 0.51; 95% CI, 0.34-0.75), vitamin E (OR, 0.44; 95% CI, 0.27-0.70), dietary fibre (OR, 0.60; 95% CI, 0.39-0.94), beta-carotene (OR, 0.55; 95% CI, 0.37-0.82), lutein (OR, 0.52; 95% CI, 0.34-0.78), and folate (OR, 0.57; 95% CI, 0.36-0.91).
Conclusion
Our results support that vegetables and related nutrients are associated with decreased risk of EC.
References
Yeh M, Moysich KB, Jayaprakash V, Rodabaugh KJ, Graham S, Brasure JR and McCann SE. Higher intakes of vegetables and vegetable-related nutrients are associated with lower endometrial cancer risks. Journal of Nutrition 139 (2): 317-22. Feb 2009.
