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Research: YOON and COLLEAGUES,
Listed in Issue 229
Abstract
YOON and COLLEAGUES, (1)Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, Korea evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose.
Background
As part of the authors’ ongoing search for natural sources of therapeutic and preventive agents for diabetic complications, they evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose.
Methodology
To identify the bioactive components of X. strumarium, 7 caffeoylquinic acids and 3 phenolic compounds were isolated and their chemical structures were elucidated on the basis of spectroscopic evidence and comparison with published data. The abilities of 10 X. strumarium-derived components to counteract diabetic complications were investigated by means of inhibitory assays with rat lens AR (rAR) and recombinant human AR (rhAR).
Results
From the 10 isolated compounds, methyl-3,5-di-O-caffeoylquinate showed the most potent inhibition, with IC₅₀ values of 0.30 and 0.67 μM for rAR and rhAR, respectively. In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/substrate, methyl-3,5-di-O-caffeoylquinate showed competitive inhibition of rhAR. Furthermore, methyl-3,5-di-O-caffeoylquinate inhibited galactitol formation in the rat lens and in erythrocytes incubated with a high concentration of glucose, indicating that this compound may be effective in preventing diabetic complications.
Conclusion
References
Yoon HN(1), Lee MY, Kim JK, Suh HW, Lim SS. Aldose reductase inhibitory compounds from Xanthium strumarium. Arch Pharm Res. Sep 2013. 36(9): 1090-5. doi: 10.1007/s12272-013-0123-5. Epub Apr 20 2013.
