Positive Health Online

Abstract

ZAGRODZKI and colleagues, Department of Food Chemistry and Nutrition, Collegium Medicum Jagiellonian University, Krakow, Poland, zagrodzk@alf.ifj.edu.pl, undertook a study to clarify whether the activities of selenoenzymes can serve as markers for different tumours or goitres, as classified by histological criteria.

Background

Methodology

The researchers determined: 1) selenium content of plasma (Se); 2) activities of the selenoenzymes plasma glutathione peroxidase (plGSHPx), cytosolic glutathione peroxidase (cGSHPx), type I and type II iodothyronine deiodinases (ID-I, ID-II) and thioredoxin reductase (THRR) in human thyroid tissues .

Results

No significant differences were found in Se or in p1GSHPx between patients and healthy volunteers. No significant differences were found for any parameter in thyroid carcinoma versus normal or goitrous thyroid tissue . In the whole group of thyroid surgery specimens, statistically significant correlations were found between ID-I and ID-II and between THRR and selenoperoxidases . Principal components analysis confirmed these correlations and also revealed correlation between Se and p1GSHPx, but did not detect any clear distinction between patients with the different diagnoses.

Conclusion

References

Zagrodzki P et al. Selenoproteins in human thyroid tissues . BioFactors 14 (1-4): 223-7. 2001.