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Research: AHANGAR and COLLEAGUES,
Listed in Issue 302
Abstract
AHANGAR and COLLEAGUES, 1. Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran; 2. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; 3. Faculty of Medicine, Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran; 4. Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran. fshaki.tox@gmail.com ; 5. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. fshaki.tox@gmail.com conducted a study to investigate the efficacy of zinc (Zn) and selenium (Se), necessary trace elements, against VPA-induced hepatotoxicity in Wistar rats.
Background
Valproic acid (VPA) is an antiepileptic drug, which its usage is limited due to its hepatotoxicity. The present study was conducted to investigate the efficacy of zinc (Zn) and selenium (Se), necessary trace elements, against VPA-induced hepatotoxicity in Wistar rats.
Methodology
The animals were divided into five groups: control, VPA 200 mg/kg, VPA + Zn (100 mg/kg), VPA + Se (100 mg/kg), and VPA + Zn + Se.
Results
The administration of VPA for four consecutive weeks resulted in decrease in serum level of Zn in rats. Also, an increase in liver marker enzymes (ALT and AST) and also histological changes in liver tissue were shown after VPA administration. Oxidative stress was evident in VPA group by increased lipid peroxidation (LPO), protein carbonyl (PCO), glutathione (GSH) oxidation, and reducing total antioxidant capacity. Zn and Se (100 mg/kg) administration was able to protect against deterioration in liver enzyme, abrogated the histological change in liver tissue, and suppressed the increase in oxidative stress markers. Zn and combination of Zn plus Se treatment showed more protective effects than Se alone.
Conclusion
These results imply that Zn and Se should be suggested as effective supplement products for the prevention of VPA-induced hepatotoxicity.
References
Ahangar N1,2, Naderi M1,2, Noroozi A1,2, Ghasemi M3, Zamani E1,2, Shaki F4,5. Zinc Deficiency and Oxidative Stress Involved in Valproic Acid Induced Hepatotoxicity: Protection by Zinc and Selenium Supplementation. Biol Trace Elem Res;179(1):102-109. doi: 10.1007/s12011-017-0944-z. Epub Jan 25 2017 . Sep 2017.
