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Research: BAYOMY and COLLEAGUES,
Listed in Issue 302
Abstract
BAYOMY and COLLEAGUES, 1. Histology department Faculty of Medicine, Tanta University, Tanta, Egypt; 2. Pharmacology department Faculty of Medicine, Suez Canal University, Ismalia, Egypt evaluated the possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy in adult male albino rats.
Background
Gentamicin nephrotoxicity accounts for 10%-15% of all cases of acute renal failure. Several natural antioxidants were found to be effective against drug-induced toxicity. The possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy were evaluated.
Methodology
Sixty-three rats were randomly divided into seven groups named: control, group II received RA 50 mg/kg/day, group III received Lyc 4 mg/kg/day, group IV received Gen 100 mg/kg/day, group V (RA + Gen), group VI (Lyc + Gen), and group VII (RA + Lyc + Gen). At the end of the experiment, kidney functions were estimated then the kidneys were sampled for histopathological, immunohistochemistry, and biochemical studies.
Results
Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin. They increased reduced glutathione, glutathione peroxidase, superoxide dismutase, and immunoexpression of the antiapoptotic protein (Bcl2). They also improved the histopathological changes induced by gentamicin.
Conclusion
The combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy. Anat Rec, 300:1137-1149, 2017.
References
Bayomy NA1, Elbakary RH1, Ibrahim MAA1, Abdelaziz EZ2. Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat. Anat Rec (Hoboken) ;300(6):1137-1149. doi: 10.1002/ar.23525. Epub Jan 19 2017. Jun 2017.
Comments: The above research demonstrated that the combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy (gentamicin).
BAYOMY and COLLEAGUES, 1. Histology department Faculty of Medicine, Tanta University, Tanta, Egypt; 2. Pharmacology department Faculty of Medicine, Suez Canal University, Ismalia, Egypt evaluated the possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy in adult male albino rats.
BACKGROUND: Gentamicin nephrotoxicity accounts for 10%-15% of all cases of acute renal failure. Several natural antioxidants were found to be effective against drug-induced toxicity. The possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy were evaluated.
METHODOLOGY: Sixty-three rats were randomly divided into seven groups named: control, group II received RA 50 mg/kg/day, group III received Lyc 4 mg/kg/day, group IV received Gen 100 mg/kg/day, group V (RA + Gen), group VI (Lyc + Gen), and group VII (RA + Lyc + Gen). At the end of the experiment, kidney functions were estimated then the kidneys were sampled for histopathological, immunohistochemistry, and biochemical studies.
RESULTS: Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin. They increased reduced glutathione, glutathione peroxidase, superoxide dismutase, and immunoexpression of the antiapoptotic protein (Bcl2). They also improved the histopathological changes induced by gentamicin.
CONCLUSIONS: The combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy. Anat Rec, 300:1137-1149, 2017.
Bayomy NA1, Elbakary RH1, Ibrahim MAA1, Abdelaziz EZ2. Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat. Anat Rec (Hoboken) ;300(6):1137-1149. doi: 10.1002/ar.23525. Epub Jan 19 2017. Jun 2017.
Comment
The above research demonstrated that the combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy (gentamicin).
