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Research: GUO and COLLEAGUES,
Listed in Issue 241
Abstract
GUO and COLLEAGUES, (1)Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China studied the expression patterns of two sodium-dependent vitamin C transporters (SVCTs) in mice after alcohol consumption.
Background
Alcoholic liver disease (ALD) is a serious liver problem in western countries. Our previous study has demonstrated that vitamin C plays a protective role in ALD. The vitamin C homeostasis is tightly regulated by sodium-dependent vitamin C transporters (SVCTs) 1 and 2. But the role of two SVCTs in ALD is less understood.
Methodology
In this study, the authors examined the expression patterns of two SVCTs in mice after alcohol consumption.
Results
Our results suggested that alcohol consumption obviously increased the expression of two SVCTs in liver and SVCT1 in kidney and intestine, which is important for vitamin C absorption. Vitamin C supplement increased the sera vitamin C content and ameliorated the symptom of ALD. Intestinal absorption and renal re-absorption mediated by SVCT1 are key factors to increase the sera vitamin C content after alcohol consumption. We proposed that both reactive oxygen species and low vitamin C concentration regulate the expression of SVCTs, and the protective role of vitamin C is mediated by suppressing the stability of hypoxia-inducible factor-1α.
Conclusion
Thus, our study is significant for the understanding of vitamin C homeostasis in ALD and for better use of other antioxidants in ALD therapy.
References
Guo X(1), Wang Y, Shen Y, Gao Y, Chang Y, Duan X. Gene expression profiles of sodium-dependent vitamin C transporters in mice after alcohol consumption. Acta Biochim Biophys Sin (Shanghai) 45(11):912-20. Nov 2013. doi: 10.1093/abbs/gmt099. Epub Sep 29 2013.
